FIRST LINE OF DEFENCE AGAINST BIOTIC AND ABIOTIC STRESSES
DR. BRUNO RUGGIERO'S DISCOVERY OF THE KEY AGRICULTURAL YIELD STABILITY GENE - NCED-3
ENHANCED PLANT STRESS-TOLERANCE TECHNOLOGY ALLOWS US TO MOVE AGRICULTURE FROM LAND TO SEA.
AROMATIC PLANTS PRODUCING 10X MORE ESSENTIAL OILS
The Osmotin plant protein was originally identified as a key plant-defence protein, and it has been studied extensively for over two decades, with numerous important publications made in top scientific journals world-wide covering its potential to revolutionize both agriculture and human health.
Find out more about our breakthrough Osmotin-rich product for the treatment of ageing-related diseases by visiting our Product Pipeline page.
Understanding plants' response to stress.
Among the first of Dr. Ruggiero's achievements in the field of plant stress physiology is the identification of the NCED-3 (9-cis-epoxycarotenoid dioxygenase) gene as a key biosynthesis regulator of Abscisic Acid (ABA) – a plant hormone responsible for plant cells’ response to stresses.
Elucidating the mechanisms of stress
Dr. Ruggiero’s work elucidates the pathway through which ABA controls growth independently from water relations, specifying, that ABA expression leads to the expression of ICK-1 (a plant growth inhibitor), which in turn, inhibits the expression of the Cyclin Kinase D2 alpha, resulting in the suppression of cell growth and cell division in plants.
Direct control of cell life and death cycles - plants and humans.
His discovery, titled Uncoupling the Effects of Abscisic Acid on Plant Growth and Water Relations. Analysis of sto1/nced3, an Abscisic Acid-Deficient but Salt Stress-Tolerant Mutant in Arabidopsis. and published in Plant Physiology (October 2004, Vol. 136, pp. 3134–3147), turned the tables on the previous presumption that osmotic imbalance directly inhibits cell growth and division to cause plant cell death. He demonstrated the existence of a direct communication between the cell nucleus and the cell membrane, capable of controlling cell growth and division, as well as cell death –independently of the water potential – suggesting, therefore, a novel way, to manipulate this pathway in order to achieve stress tolerance. A similar pathway is also active in humans, and is considered by many one of the principal causes of ageing.
The first NCED-3 plant mutant - the beginning of a revolution.
In Dr. Ruggiero’s publication mentioned above, he also identified and described the atNCED- 3/STO1 mutant – an Arabidopsis thaliana plant mutant, in which the gene NCED-3 is rendered inactive by a T-DNA insertion. This mutant is currently in the Salk Institute’s collection, and is being used in many laboratories across the United States and worldwide for research in plant stress physiology to improve crop yield and resistance to drought and salinity, improve crop flavor, and other agricultural applications.
Market entry and global use
Dr. Ruggiero's NCED-3 technology is being applied on a global scale by nonprofit and for profit institutions, from agricultural multinationals to improve crop yield stability to the development of coffee varieties with increased flavor; as well as in research performed by national and international research foundations; all with the objective of improving crop production and qualities in a variety of plant species. The NCED-3 DNA gene sequence detection kit is globally available for purchase for scientific and research purposes, marketed and available for purchase from Taqman®.
Dr. Ruggiero's discovery became the founding technology in FuturaGene's IP portfolio and a driving force behind its IPO on the London Stock Exchange's Alternative Investment Market in 2004 as one of the first biotech start ups in the world, where FGN's stock launched at 38p, reaching 2+ GBP.
Contact us to learn more about NCED-3
9D Biotech has the long-term goal of revolutionizing agriculture through the use of Dr. Ruggiero's discoveries as a platform to develop and launch a system of Sustainable Ocean Cropping.
o 78% of all the clean water in the world is used for agriculture, placing a limit on population growth and urbanization, as well as wild life preservation.
o Two thirds of our planet are covered with salt water, yet paradoxically, at the moment, this water cannot be used for irrigation because its salinity would cause an ecological disaster.
The only solution is to move crop production from land to the seas and oceans.
INTRODUCING THE SUSTAINABLE OCEAN CROPPING RESEARCH PROJECT
Our goal is to develop specially designed floating rafts for intense cultivation of our seawater tolerant crop species.
The development of corn, tomatoes, soybeans, rice, cotton, etc. capable of thriving on seawater is within our reach thanks to our collaboration with our University partners and Dr. Ruggiero’s discoveries. The main advantages of our Sustainable Ocean Cropping project include:
o Removing the burden of intensive farming from the land;
o Dramatically reducing pollution and the depletion of natural resources;
o Reinstating the land back to human and wild life use;
o Fighting oceanic “dead zones” caused by excessive nitrogen and phosphorus contamination from current agricultural practices.
9D Biotech's Sustainable Ocean Cropping Project has been endorsed by a international VC group for implementation directly in the San Francisco Bay, envisioning cultivation of crops such as salt-tolerant tomatoes with Dr. Ruggiero's NCED-3 technology.
Contact us to learn more about Sustainable Ocean Cropping.
9D Biotech is currently developing a novel commercial plant variety with in-house technology allowing us to boost plants' essential oil production capabilities by a factor of 13 with applications in nearly every major market: from beauty, to health, to landscaping and agriculture.