INDEPENDENT R&D

This page offers a comprehensive selection of relevant scientific, peer-reviewed publications describing the function of the key human hormone Adiponectin and that of its plant counterpart - the powerful protein Osmotin.

OSMOTIN AS A PLANT DERIVED THERAPEUTIC PROTEIN 

Click on the links below to learn about Osmotin's therapeutic activity:

• Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis.

• The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer's Disease.

• Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease. 

• Osmotin attenuates amyloid beta- induced memory impairment, tau phosphorylation and neurodegeneration in the mouse  hippocampus

• Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

• Neuroprotective effect of osmotin against ethanol-induced apoptotic neurodegeneration in the developing rat brain

• Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain  

• Adiponectin and Plant-Derived Mammalian Adiponectin Homolog Exert a Protective Effect in Murine Colitis   

ADIPONECTIN - THE LIFESPAN REGULATOR 

Follow the links below to read international published research on Adiponectin - the key life-span regulator - and its receptors:

• Adiponectin and Adiponectin Receptors

• Adiponectin/adiponectin receptor in disease and aging

• Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome