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9th Dimension Biotech, Inc.
  • WELCOME
  • THE TEAM
    • CHIEF EXECUTIVE OFFICER
    • COMPANY PRESIDENT
    • CHIEF PHYSICIAN ADVISOR
    • CLINICAL NEUROSCIENCE
    • BIOTECHNOLOGY ADVISOR
    • CHIEF FINANCIAL OFFICER
  • ABOUT FORZA
  • THE REVIEWS
  • THE STORY
  • INDEPENDENT R&D
  • THE SOURCE
  • THE PLAN
  • THE PRODUCTION
  • ABOUT US
  • WEBINARS
    • WEBINAR GALLERY
    • THE BIOLOGY OF AGING
    • ALZHEIMER'S DISEASE
    • PARKINSON'S DISEASE
    • DEPRESSION
    • FRONTOTEMPORAL DEMENTIAS
  • SHOP
  • CONTACT US
  • NEWS

THE BIOLOGY OF AGING


A 2-PART SERIES OF SEMINARS BY DR. DOUGLAS WATT, PH.D.

THE BIOLOGY OF AGING PART 1 OF 2

THE BIOLOGY OF AGING PART 1 OF 2

THE BIOLOGY OF AGING PART 1 OF 2

Aging, Calorie Restriction, and the Diseases of Aging - the Promise of Calorie-Restriction Mimetics.

PART 1

THE BIOLOGY OF AGING PART 2 OF 2

THE BIOLOGY OF AGING PART 1 OF 2

THE BIOLOGY OF AGING PART 1 OF 2

Neurodegeneration - the amyloid hypotheses. A primary failure of proteostasis. 

PART 2

THE DISEASES OF AGING AND THE PROMISE OF CR MIMETICS.

Implications for Healthcare in the 21st Century – Synergisms with Lifestyle Change.

Western healthcare systems are losing a battle against chronic disease, driven in good part by skyrocketing rates of diaobesity (the ubiquitous conjoining of obesity with type II diabetes), and a profound mismatch between our genome and the modern environment. Of the four critical lifestyle variables (diet, exercise, sleep, and social support versus social stress) only two get any attention in primary care, and oftentimes even those are neglected. How can we change a losing game?


- By Douglas F. Watt, Ph.D.

Adjunct Professor Graduate Department of Psychology Lesley University

Clinical Neuroscience Advisor 9th Dimension Biotech, Inc.

AGING, CALORIE RESTRICTION, AND THE DISEASES OF AGING.

THE PROMISE OF CALORIE-RESTRICTION MIMETICS.

 PART 1 OF 2

By Dr. Douglas Watt, Ph.D. 

Adjunct Professor, Graduate Department of Psychology Lesley University 

Clinical Neuroscience Advisor, 9th Dimension Biotech, Inc.  


Highlights:  


  • THE BIOLOGY OF AGING AND THE OVERLAPPING MECHANISMS OF AGE-RELATED DISEASE.


  • THE OBESITY CRISIS.  


  • WHY WE ARE LOSING THE BATTLE AGAINST THE DISEASES OF AGING - AND WHAT WE CAN DO DIFFERENTLY.

THE CALORIE RESTRICTION RESPONSE AND PHYSIOLOGY

THE SYNERGISM OF LIFESTYLE CHANGE AND CALORIE RESTRICTION MIMETICS

 PART 2 OF 2

By Dr. Douglas Watt, Ph.D. 

Adjunct Professor, Graduate Department of Psychology Lesley University 

Clinical Neuroscience Advisor, 9th Dimension Biotech, Inc.  


Highlights:  


  • CALORIE-RESTRICTION (CR) MIMETICS - WITH A SPECIAL FOCUS ON ADIPONECTIN AND OSMOTIN.  


  • THE SYNERGISMS OF LIFESTYLE CHANGE AND CR MIMETICS.  


In Part II, we dive into the Alice-in-Wonderland world of cell signals and the (growing) complexity of how cells regulate and organize a bevy of responses to environmental signals – this is clearly part of evolutionary adaptation to shifting environs.  We focus specifically on the calorie restriction (CR) response, which is conserved across phylogeny, and on substances that may at least partially mimic CR, termed CR mimetics.  To understand these issues better, we need to review the still young and emerging science of mTOR, and the networks around it, and how AMPK, surtuins, other transcription factors and signals create a catabolic cell signaling space counterposed to the fundamental vectors of mTOR, with long term and major health benefits.  Harsh blockade of mTOR may be very bad for us, but long term disinhibition – as in obesity, DMII, CAD, CA, and neurodegenerative disorders (most age-related disease) – looks very bad also.  Tonic or pulsatile restraint on mTOR with some permission for growth signals (critical to tissue repair/maintenance and decent neuroplasticity) but with concomitant upregulation of autophagy (cellular ‘trash disposal’) and strong dampening of ‘inflammaging’ appears a difficult but highly desirable ‘sweet spot’ – once again the Greeks were prescient in their advocacy for moderation in all things.  We look at Adiponectin as an emerging and fairly recently confirmed critical player in this CR catabolic process, with interactions with AMPK and several PPARs, and how Osmotin may offer critical avenues for agonist effects on AdPN receptor families.  Many questions remain, and much scientific and technical opportunity lies ahead. 

WEBINAR GALLERY

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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